Article
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.
American journal of human genetics - 1 Sept 2008
Nelson Matthew R, Bryc Katarzyna, King Karen S, Indap Amit, Boyko Adam R, Novembre John, Briley Linda P, Maruyama Yuka, Waterworth Dawn M, Waeber Gérard, Vollenweider Peter, Oksenberg Jorge R, Hauser Stephen L, Stirnadel Heide A, Kooner Jaspal S, Chambers John C, Jones Brendan, Mooser Vincent, Bustamante Carlos D, Roses Allen D, Burns Daniel K, Ehm Margaret G, Lai Eric H
Abstract excerpt
Technological and scientific advances, stemming in large part from the Human Genome and HapMap projects, have made large-scale, genome-wide investigations feasible and cost effective. These advances have the potential to dramatically impact drug discovery and development by identifying genetic factors that contribute to variation in disease risk as well as drug pharmacokinetics, treatment efficacy, and adverse...
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