Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systems genetics of the Drosophila metabolome.

Genome research - 1 Mar 2020

Zhou Shanshan, Morgante Fabio, Geisz Matthew S, Ma Junwu, Anholt Robert R H, Mackay Trudy F C

Abstract excerpt

How effects of DNA sequence variants are transmitted through intermediate endophenotypes to modulate organismal traits remains a central question in quantitative genetics. This problem can be addressed through a systems approach in a population in which genetic polymorphisms, gene expression traits, metabolites, and complex phenotypes can be evaluated on the same genotypes. Here, we focused on the metabolome,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Genetic Association Studies
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Metabolome

Share to Phenotype

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 31694867
DOI: 10.1101/gr.243030.118
PMCID: PMC7111526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systems genetics of the Drosophila metabolome.PMID 31694867Read ↗

Prediction of complex phenotypes using the Drosophila melanogaster metabolome.Semantic proximity Read ↗

Prediction of complex phenotypes using the <i>Drosophila</i> metabolomeSemantic proximity Read ↗

Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster.Semantic proximity Read ↗

Metabolomic and Gene Expression Profiles Exhibit Modular Genetic and Dietary Structure Linking Metabolic Syndrome Phenotypes in Drosophila.Semantic proximity Read ↗

The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster.Semantic proximity Read ↗

Systems genetics of complex traits in Drosophila melanogaster.Semantic proximity Read ↗

Evolution of Metabolome and Transcriptome Supports a Hierarchical Organization of Adaptive Traits.Semantic proximity Read ↗

Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parent Drosophila Synthetic Population Resource determines that main genetic effects are distinct from environment dependent plastic lociSemantic proximity Read ↗

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humansSemantic proximity Read ↗

The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster.Semantic proximity Read ↗

Alcohol sensitivity in Drosophila: translational potential of systems genetics.Semantic proximity Read ↗

Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.