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Article

Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach

30 Jul 2018

Abstract excerpt

Alcohol use disorder (AUD) is a complex psychiatric disorder with strong genetic and environmental risk factors. We studied the molecular perturbations underlying risky drinking behavior by measuring transcriptome changes across the neurocircuitry of addiction in a genetic mouse model of binge drinking. Sixteen generations of selective breeding for high blood alcohol levels after a binge drinking session produced...

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PMID: 30062672
DOI: 10.1007/s12035-018-1252-0

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