The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies.

doi:10.1093/ije/dyp265

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Article

The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies.

International journal of epidemiology - 1 Oct 2009

Rice Neil E, Bandinelli Stefania, Corsi Anna Maria, Ferrucci Luigi, Guralnik Jack M, Miller Michelle A, Kumari Meena, Murray Anna, Frayling Tim M, Melzer David

Abstract excerpt

BACKGROUND: The human paraoxonase (PON1) protein detoxifies certain organophosphates, and the PON1 Q192R polymorphism (rs662) affects PON1 activity. Groups with higher dose exposure to organophosphate sheep dips or first Gulf War nerve toxins reported poorer health if they had 192R, and these associations have been used to exemplify Mendelian randomization analysis. However, a reported association of 192R with...

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PMID: 19651761
DOI: 10.1093/ije/dyp265
PMCID: PMC2755129

Genes

PON1

Variants

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