Article
Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism-smoking interactions differentially predict the odds of major depression and bipolar disorder.
Journal of affective disorders - 1 Apr 2014
Bortolasci Chiara Cristina, Vargas Heber Odebrecht, Souza-Nogueira André, Barbosa Décio Sabbatini, Moreira Estefania Gastaldello, Nunes Sandra Odebrecht Vargas, Berk Michael, Dodd Seetal, Maes Michael
Abstract excerpt
BACKGROUND: Major depression and bipolar disorder are accompanied by the activation of immune-inflammatory and Oxidative and Nitrosative Stress (O&NS) pathways and lowered levels of antioxidants. Paraoxonase (PON)1 (EC 3.1.8.1) is an antioxidant bound to High Density Lipoprotein (HDL). Polymorphisms in the PON1 Q192R coding sequence determine three functional genotypes, i.e. 192QQ, 192QR and 192RR. AIMS: This...
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