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Article

[Phenotypic Variants of Paraoxonase Q192R in Bipolar Disorder,Depression and Schizophrenia].

Turk psikiyatri dergisi = Turkish journal of psychiatry - 1 Jan 2018

Atagün Murat İlhan, Tunç Serhat, Alışık Murat, Erel Özcan

Abstract excerpt

OBJECTIVE: Activity of the paraoxonase 1 (PON1) enzyme varies prominently according to the PON1 Q192R genotype. The arginine (R) genotype hydrolyzes peroxided lipids more quickly and efficiently than the glutamine (Q) genotype. The Q phenotype suggests greater liability to neurodegenerative processes, cardiovascular and malignancy risks than the R phenotype. Stimulated PON/ARES ratio is associated with the PON1...

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PMID: 30215835

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