High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase

Abstract excerpt

Telomerase is considered an attractive anticancer target on the basis of its common and specific activation in most human cancers. While direct telomerase inhibition is being explored as a therapeutic strategy, alternative strategies to target regulators of telomerase that could disrupt telomere maintenance and cancer cell proliferation are not yet available. Here, we report the findings of a high-throughput...

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• Share to Advanced biosensing and bioanalysis techniques
• Share to RNA Interference and Gene Delivery
• Share to Telomeres, Telomerase, and Senescence