Article
The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging?
Medical hypotheses - 1 Dec 2009
Bajić Vladan P, Spremo-Potparević Biljana, Zivković Lada, Bonda David J, Siedlak Sandra L, Casadesus Gemma, Lee Hyoung-Gon, Smith Mark A
Abstract excerpt
Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization...
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