Article
Cyclin' toward dementia
1 Jan 2000
Abstract excerpt
Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal vulnerability in Alzheimer disease, a chronic neurodegeneration. Such ectopic localization of various cyclins, cyclin-dependent kinases, and cyclin inhibitors in neurons can be seen as an attempt to re-enter the cell cycle. Given that primary neurons are terminally differentiated, any attempted...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
