The roles played by the D2 and D3 domains of recombinant human thrombomodulin in its function.

doi:10.1093/jb/118.5.1030

Back to search

Article

The roles played by the D2 and D3 domains of recombinant human thrombomodulin in its function.

Journal of biochemistry - 1 Nov 1995

Honda G, Masaki C, Zushi M, Tsuruta K, Sata M

Abstract excerpt

Thrombomodulin (TM) is composed of five domains. We investigated the roles of the sixth epidermal growth factor (EGF)-like structure (E6) in the second domain (D2) and of an O-glycosylation site rich domain (D3) in the function of TM in more detail using deletion analysis. Two soluble mutants of...

Topics

Anticoagulants
Cell Line
Epidermal Growth Factor
Glycosylation
Humans
Mutation
Protein C
Protein Structure, Tertiary
Recombinant Proteins
Solubility
Structure-Activity Relationship
Thrombomodulin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.