Article
Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin.
The Journal of biological chemistry - 15 Jul 1993
Lentz S R, Chen Y, Sadler J E
Abstract excerpt
Activation of protein C by thrombin is stimulated by the endothelial cell cofactor thrombomodulin. The structural regions of thrombomodulin necessary for cofactor activity have been localized to the fourth through sixth epidermal growth factor (EGF)-like domains. The fourth EGF-like domain is unn...
Topics
- Amino Acid Sequence
- Anticoagulants
- Cells, Cultured
- Cloning, Molecular
- Disulfides
- Epidermal Growth Factor
- Fibrinogen
- Humans
- Molecular Sequence Data
- Mutation
- Protein C
- Protein Conformation
- Receptors, Cell Surface
- Receptors, Thrombin
- Recombinant Proteins
- Sequence Homology, Amino Acid
- Thrombin