Article
Mutation detection of KRAS by high-resolution melting analysis in Chinese with gastric cancer.
Oncology reports - 1 Sept 2009
Liu Zhi-Min, Liu Li-Na, Li Mei, Zhang Qiu-Ping, Cheng Shi-Hua, Lu Shen
Abstract excerpt
KRAS proteins play an important role in regulating cell functions. A series of studies has revealed that mutations of KRAS are involved in gastric carcinogenesis. However, mutation status of KRAS remains unclear in gastric cancer from Chinese Mainland. It has been proved that KRAS mutation associates with resistance to epidermal growth factor receptor (EGFR) inhibitors. In this study, KRAS mutations were detected...
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