Article
Sensitive and specific KRAS somatic mutation analysis on whole-genome amplified DNA from archival tissues.
The Journal of molecular diagnostics : JMD - 1 Jan 2010
van Eijk Ronald, van Puijenbroek Marjo, Chhatta Amiet R, Gupta Nisha, Vossen Rolf H A M, Lips Esther H, Cleton-Jansen Anne-Marie, Morreau Hans, van Wezel Tom
Abstract excerpt
Kirsten RAS (KRAS) is a small GTPase that plays a key role in Ras/mitogen-activated protein kinase signaling; somatic mutations in KRAS are frequently found in many cancers. The most common KRAS mutations result in a constitutively active protein. Accurate detection of KRAS mutations is pivotal to the molecular diagnosis of cancer and may guide proper treatment selection. Here, we describe a two-step KRAS...
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