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Article

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Science signaling - 28 Jul 2009

Kiel Christina, Serrano Luis

Abstract excerpt

We generated 17 c-Raf (RAF proto-oncogene serine-threonine protein kinase) mutants with altered Ras-Raf association and dissociation rates to investigate the role of electrostatically driven Ras-Raf association rates on epidermal growth factor (EGF)-activated mitogen-activated protein kinase (MAPK) signal transduction. Some of these mutants had compensating changes in association and dissociation rates, enabling...

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Source

Identifiers

PMID: 19638615
DOI: 10.1126/scisignal.2000397

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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