Article
Improved binding of raf to Ras.GDP is correlated with biological activity.
The Journal of biological chemistry - 13 Nov 2009
Kiel Christina, Filchtinski Daniel, Spoerner Michael, Schreiber Gideon, Kalbitzer Hans Robert, Herrmann Christian
Abstract excerpt
The GTP-binding protein Ras plays a central role in the regulation of various cellular processes, acting as a molecular switch that triggers signaling cascades. Only Ras bound to GTP is able to interact strongly with effector proteins like Raf kinase, phosphatidylinositol 3-kinase, and RalGDS, whereas in the GDP-bound state, the stability of the complex is strongly decreased, and signaling is interrupted. To...
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