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Article

Allosteric activation of functionally asymmetric RAF kinase dimers.

Cell - 29 Aug 2013

Hu Jiancheng, Stites Edward C, Yu Haiyang, Germino Elizabeth A, Meharena Hiruy S, Stork Philip J S, Kornev Alexandr P, Taylor Susan S, Shaw Andrey S

Abstract excerpt

Although RAF kinases are critical for controlling cell growth, their mechanism of activation is incompletely understood. Recently, dimerization was shown to be important for activation. Here we show that the dimer is functionally asymmetric with one kinase functioning as an activator to stimulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23993095
DOI: 10.1016/j.cell.2013.07.046
PMCID: PMC3844432

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23993095-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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