Article
Targeted high throughput sequencing of a cancer-related exome subset by specific sequence capture with a fully automated microarray platform.
Genomics - 1 Apr 2010
Summerer Daniel, Schracke Nadine, Wu Haiguo, Cheng Yang, Bau Stephan, Stähler Cord F, Stähler Peer F, Beier Markus
Abstract excerpt
Sequence capture methods for targeted next generation sequencing promise to massively reduce cost of genomics projects compared to untargeted sequencing. However, evaluated capture methods specifically dedicated to biologically relevant genomic regions are rare. Whole exome capture has been shown to be a powerful tool to discover the genetic origin of disease and provides a reduction in target size and thus...
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