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Article

A Method for Extending Target Regions of Genomic Profiling by Combining a Custom Probe Pool with a Commercial Targeted Panel.

The journal of applied laboratory medicine - 2 Nov 2023

Kukita Yoji, Kunimasa Kei, Akazawa Takashi, Mizote Yu, Tahara Hideaki

Abstract excerpt

BACKGROUND: Next-generation sequencing (NGS)-based genomic profiling is becoming widespread in determining treatment policies for patients with tumors. Commercially available gene panels for pan-tumor targets comprise hundreds of tumor-related genes but frequently lack genes of interest in specific tumor types. In this study, we demonstrate a method for extending target regions of genomic profiling by combining a...

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PMID: 37748758
DOI: 10.1093/jalm/jfad069

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