Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries.

Nucleic acids research - 1 Jun 2010

Mokry Michal, Feitsma Harma, Nijman Isaac J, de Bruijn Ewart, van der Zaag Pieter J, Guryev Victor, Cuppen Edwin

Abstract excerpt

Microarray-based enrichment of selected genomic loci is a powerful method for genome complexity reduction for next-generation sequencing. Since the vast majority of exons in vertebrate genomes are smaller than 150 nt, we explored the use of short fragment libraries (85-110 bp) to achieve higher enrichment specificity by reducing carryover and adverse effects of flanking intronic sequences. High enrichment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Mutation

Share to Oligonucleotide Array Sequence Analysis

Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 20164091
DOI: 10.1093/nar/gkq072
PMCID: PMC2879533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries.PMID 20164091Read ↗

High-throughput, high-accuracy array-based resequencing.Semantic proximity Read ↗

Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing.Semantic proximity Read ↗

Comparison of commercially available target enrichment methods for next-generation sequencing.Semantic proximity Read ↗

Microarray-based genomic selection for high-throughput resequencing.Semantic proximity Read ↗

High-throughput discovery of rare insertions and deletions in large cohorts.Semantic proximity Read ↗

Massively parallel sequencing of ataxia genes after array-based enrichment.Semantic proximity Read ↗

High-performance single-chip exon capture allows accurate whole exome sequencing using the Illumina Genome Analyzer.Semantic proximity Read ↗

Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags.Semantic proximity Read ↗

Comparison of three targeted enrichment strategies on the SOLiD sequencing platform.Semantic proximity Read ↗

A genome-wide scalable SNP genotyping assay using microarray technology.Semantic proximity Read ↗

SNP Discovery from Single and Multiplex Genome Assemblies of Non-model Organisms.Semantic proximity Read ↗

Efficient targeted resequencing of human germline and cancer genomes by oligonucleotide-selective sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.