Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.

doi:10.1096/fj.201500138RR

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2016

Ganz Ariel B, Shields Kelsey, Fomin Vlad G, Lopez Yusnier S, Mohan Sanjay, Lovesky Jessica, Chuang Jasmine C, Ganti Anita, Carrier Bradley, Yan Jian, Taeswuan Siraphat, Cohen Vanessa V, Swersky Camille C, Stover Julie A, Vitiello Gerardo A, Malysheva Olga V, Mudrak Erika, Caudill Marie A

Abstract excerpt

Although single nucleotide polymorphisms (SNPs) in folate-mediated pathways predict susceptibility to choline deficiency during severe choline deprivation, it is unknown if effects persist at recommended intakes. Thus, we used stable isotope liquid chromatography-mass spectrometry (LC-MS) methodology to examine the impact of candidate SNPs on choline metabolism in a long-term, randomized, controlled feeding trial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Betaine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Choline

Share to Diet

Share to Folic Acid

Share to Folic Acid Deficiency

Share to Lactation

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Phosphatidylcholines

Source

Open in PubMed Open full text

Identifiers

PMID: 27342765
DOI: 10.1096/fj.201500138RR
PMCID: PMC5024689

Genes

MTR
MTHFD1
MTHFR
MTRR
PEMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.PMID 27342765Read ↗

Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.Semantic proximity Read ↗

Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements.Semantic proximity Read ↗

Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.Semantic proximity Read ↗

Choline metabolitesSemantic proximity Read ↗

Nutritional genomics: defining the dietary requirement and effects of choline.Semantic proximity Read ↗

Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.Semantic proximity Read ↗

Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women.Semantic proximity Read ↗

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones.Semantic proximity Read ↗

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.Semantic proximity Read ↗

Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice.Semantic proximity Read ↗

Common genetic polymorphisms affect the human requirement for the nutrient choline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.