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Article

Dietary choline requirements of women: effects of estrogen and genetic variation.

The American journal of clinical nutrition - 1 Nov 2010

Fischer Leslie M, da Costa Kerry-Ann, Kwock Lester, Galanko Joseph, Zeisel Steven H

Abstract excerpt

BACKGROUND: Choline is obtained from the diet and from the biosynthesis of phosphatidylcholine. Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by estrogen. Because they have lower estrogen concentrations, postmenopausal women are more susceptible to the risk of organ dysfunction in response to a low-choline diet. A common genetic polymorphism...

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Identifiers

PMID: 20861172
DOI: 10.3945/ajcn.2010.30064
PMCID: PMC2954445

Genes

PEMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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