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Article

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development.

Oncogene - 10 Oct 2013

Rubio R, Gutierrez-Aranda I, Sáez-Castillo A I, Labarga A, Rosu-Myles M, Gonzalez-Garcia S, Toribio M L, Menendez P, Rodriguez R

Abstract excerpt

Increasing evidence suggests that mesenchymal stem/stromal cells (MSCs) carrying specific mutations are at the origin of some sarcomas. We have reported that the deficiency of p53 alone or in combination with Rb (Rb(-/-) p53(-/-)) in adipose-derived MSCs (ASCs) promotes leiomyosarcoma-like tumors in vivo. Here, we hypothesized that the source of MSCs and/or the cell differentiation stage could determine the...

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Identifiers

PMID: 23222711
DOI: 10.1038/onc.2012.507

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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