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Article

Stabilized gene duplication enables long-term selection-free heterologous pathway expression.

Nature biotechnology - 1 Aug 2009

Tyo Keith E J, Ajikumar Parayil Kumaran, Stephanopoulos Gregory

Abstract excerpt

Engineering robust microbes for the biotech industry typically requires high-level, genetically stable expression of heterologous genes and pathways. Although plasmids have been used for this task, fundamental issues concerning their genetic stability have not been adequately addressed. Here we d...

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PMID: 19633654
DOI: 10.1038/nbt.1555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19633654-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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