Article
Evolutionary genome engineering using a restriction-modification system.
Nucleic acids research - 1 Nov 2011
Asakura Yoko, Kojima Hiroyuki, Kobayashi Ichizo
Abstract excerpt
Modification of complex microbial cellular processes is often necessary to obtain organisms with particularly favorable characteristics, but such experiments can take many generations to achieve. In the present article, we accelerated the experimental evolution of Escherichia coli populations under selection for improved growth using one of the restriction-modification systems, which have shaped bacterial...
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