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Article

Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus.

Molecular biology of the cell - 1 Mar 2009

del Toro Daniel, Alberch Jordi, Lázaro-Diéguez Francisco, Martín-Ibáñez Raquel, Xifró Xavier, Egea Gustavo, Canals Josep M

Abstract excerpt

Huntingtin regulates post-Golgi trafficking of secreted proteins. Here, we studied the mechanism by which mutant huntingtin impairs this process. Colocalization studies and Western blot analysis of isolated Golgi membranes showed a reduction of huntingtin in the Golgi apparatus of cells expressing mutant huntingtin. These findings correlated with a decrease in the levels of optineurin and Rab8 in the Golgi...

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Identifiers

PMID: 19144827
DOI: 10.1091/mbc.e08-07-0726
PMCID: PMC2649260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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