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Article

Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1.

Molecular pharmacology - 1 Nov 2007

Kong Michael M C, Hasbi Ahmed, Mattocks Michael, Fan Theresa, O'Dowd Brian F, George Susan R

Abstract excerpt

There is accumulating evidence that G protein-coupled receptor signaling is regulated by localization in lipid raft microdomains. In this report, we determined that the D1 dopamine receptor (D1R) is localized in caveolae, a subset of lipid rafts, by sucrose gradient fractionation and confocal microscopy. Through coimmunoprecipitation and bioluminescence resonance energy transfer assays, we demonstrated that this...

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PMID: 17699686
DOI: 10.1124/mol.107.034769

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