Article
Analysis of mGluR1a constitutive internalization using a pulse-chase enzyme-linked immuno-sorbant assay (ELISA).
Journal of biochemical and biophysical methods - 30 Sept 2005
Pula Giordano, Mundell Stuart J, Roberts Peter J, Kelly Eamonn
Abstract excerpt
The surface expression of G protein-coupled receptors is regulated by internalization. For many receptors, a constitutive level of internalization in the absence of agonist has been reported. The constitutive internalization of metabotropic glutamate receptor 1a (mGluR1a) has been described, but in general little attention has been dedicated to this important aspect of receptor regulation. Here we describe a...
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