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Article

Lipid rafts serve as signaling platforms for mGlu1 receptor-mediated calcium signaling in association with caveolin.

Molecular brain - 10 Feb 2014

Roh Seung-Eon, Hong Yun Hwa, Jang Dong Cheol, Kim Jun, Kim Sang Jeong

Abstract excerpt

BACKGROUND: Group I metabotropic glutamate receptors (mGlu1/5 receptors) have important roles in synaptic activity in the central nervous system. They modulate neuronal excitability by mobilizing intracellular Ca2+ following receptor activation. Also, accumulating evidence has indicated the association of Ca2+ signaling with lipid rafts. Caveolin, an adaptor protein found in a specialized subset of lipid rafts,...

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Identifiers

PMID: 24512690
DOI: 10.1186/1756-6606-7-9
PMCID: PMC3937055

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