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Article

Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study.

International journal of cancer - 1 May 2010

Zheng Yun-Ling, Kosti Ourania, Loffredo Christopher A, Bowman Elise, Mechanic Leah, Perlmutter Donna, Jones Raymond, Shields Peter G, Harris Curtis C

Abstract excerpt

Cell cycle checkpoints play critical roles in the maintenance of genomic integrity and inactivation of checkpoint genes are frequently perturbed in most cancers. In a case-control study of 299 non-small cell lung cancer cases and 550 controls in Baltimore, we investigated the association between...

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Identifiers

PMID: 19626602
DOI: 10.1002/ijc.24771
PMCID: PMC2950001

Genes

ATM
BRCA2
ERCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19626602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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