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Less Efficient G2-M Checkpoint Is Associated with an Increased Risk of Lung Cancer in African Americans

15 Oct 2005

Abstract excerpt

Cell cycle checkpoints play critical roles in the maintenance of genomic integrity. The inactivation of checkpoint genes by genetic and epigenetic mechanisms is frequent in all cancer types, as a less-efficient cell cycle control can lead to genetic instability and tumorigenesis. In an on-going case-control study consisting of 216 patients with non-small cell lung cancer, 226 population-based controls, and 114...

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PMID: 16230422
DOI: 10.1158/0008-5472.can-05-1003

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