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Article

Regulation of TIR-1/SARM-1 by miR-71 Protects Dopaminergic Neurons in a C. elegans Model of LRRK2-Induced Parkinson's Disease.

International journal of molecular sciences - 13 Aug 2024

Naidoo Devin, de Lencastre Alexandre

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by symptoms such as bradykinesia, resting tremor, and rigidity, primarily driven by the degradation of dopaminergic (DA) neurons in the substantia nigra. A significant contributor to familial autosomal dominant PD cases is mutations in the LRRK2 gene, making it a primary therapeutic target. This study explores the role of microRNAs...

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Identifiers

PMID: 39201481
DOI: 10.3390/ijms25168795
PMCID: PMC11354575

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