Article
Single molecule PCR in mtDNA mutational analysis: Genuine mutations vs. damage bypass-derived artifacts.
Methods (San Diego, Calif.) - 1 Dec 2008
Kraytsberg Y, Nicholas A, Caro P, Khrapko K
Abstract excerpt
The area of somatic mtDNA mutation measurement is in a crisis because the methods used to quantify mtDNA mutations produce results varying by multiple orders of magnitude. The reason for these discrepancies is not clear, but given that most methods involve PCR, the prime suspect is PCR artifacts...
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