Article
Accumulation of mutations over the entire mitochondrial genome of breast cancer cells obtained by tissue microdissection.
Breast cancer research and treatment - 1 Jul 2011
Fendt Liane, Niederstätter Harald, Huber Gabriela, Zelger Bettina, Dünser Martina, Seifarth Christof, Röck Alexander, Schäfer Georg, Klocker Helmut, Parson Walther
Abstract excerpt
The occurrence of heteroplasmy and mixtures is technically challenging for the analysis of mitochondrial DNA. More than that, observed mutations need to be carefully interpreted in the light of the phylogeny as mitochondrial DNA is a uniparental marker reflecting human evolution. Earlier attempts to explain the role of mtDNA in cancerous tissues led to substantial confusion in medical genetics mainly due to the...
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