Article
The 8-hydroxydeoxyguanosine concentrations according to hormone therapy and S326C polymorphism of OGG1 gene in postmenopausal women.
Molecular genetics and metabolism - 1 Dec 2011
Kim Hoon, Ku Seung-Yup, Kang Jong Won, Kim Heon, Kim Yong Dae, Kim Seok Hyun, Choi Young Min, Kim Jung Gu, Moon Shin Yong
Abstract excerpt
BACKGROUND: The 8-hydroxydeoxyguanosine (8-OHdG) is widely used for determination of DNA damage since it is excised from oxidative damaged DNA with endonuclease repair enzymes coded by 8-oxoguanine DNA N-glycosylase gene (OGG1). The present study aimed at investigating whether hormone therapy (HT) may influence on the blood/urinary 8-OHdG levels and whether the level of 8-OHdG is different according to OGG1 S326C...
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