Article
Genetic variations in angiogenesis pathway genes associated with clinical outcome in localized gastric adenocarcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 2010
Lurje G, Husain H, Power D G, Yang D, Groshen S, Pohl A, Zhang W, Ning Y, Manegold P C, El-Khoueiry A, Iqbal S, Tang L H, Shah M A, Lenz H-J
Abstract excerpt
BACKGROUND: Angiogenesis has been attributed to be a well-recognized aspect of human cancer biology. As such, proteinase-activated receptor (PAR)-1, endostatin (ES) and interleukin-8 (IL-8) mediate the regulation of early-onset angiogenesis and in turn impact the process of tumor-growth and disease progression. PATIENTS AND METHODS: Formalin-fixed paraffin-embedded tissues were obtained from 137 patients with...
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