Article
Tumor angiogenesis genotyping and efficacy of first-line chemotherapy in metastatic gastric cancer patients.
Pharmacogenomics - 1 Dec 2013
Scartozzi Mario, Giampieri Riccardo, Loretelli Cristian, Bittoni Alessandro, Mandolesi Alessandra, Faloppi Luca, Bianconi Maristella, Del Prete Michela, Andrikou Kalliopi, Bearzi Italo, Cascinu Stefano
Abstract excerpt
AIM: Besides correlating with prognosis, tumor-driven angiogenesis also seemed able to influence response/resistance to chemotherapy in preclinical models. We examined the role of tumor angiogenesis genotyping in determining clinical outcome in metastatic gastric cancer patients receiving first-line chemotherapy. PATIENTS & METHODS: VEGF-A, VEGF-C, FLT1, KDR and FLT4 genotyping was analyzed in gastric tumors from...
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