Article
Pharmacogenetic angiogenesis profiling for first-line chemotherapy in patients with advanced gastric cancer.
Cancer investigation - 1 Jul 2013
Dan Su, Bai Li, Li-Jie Wang, Ting Zhang, Zhi-Yuan Mao
Abstract excerpt
We retrospectively investigated germline polymorphisms in angiogenesis pathway genes (14 SNPs) and their correlation to clinical outcome (progression free survival and overall survival) in 128 patients with unresectable-advanced gastric carcinoma (AGC) treated with first-line chemotherapy. Our analysis revealed that Endostatin +4349 G>A polymorphism exhibited a worse progression free survival (PFS) and overall...
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