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Article

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

Cell stem cell - 7 Jun 2007

Ruzankina Yaroslava, Pinzon-Guzman Carolina, Asare Amma, Ong Tony, Pontano Laura, Cotsarelis George, Zediak Valerie P, Velez Marielena, Bhandoola Avinash, Brown Eric J

Abstract excerpt

Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (Seckel syndrome). Here we show that eliminating ATR in adult mice leads to defects in tissue homeostasis and the rapid appearance of age-related phenotypes, such as hair...

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Source

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Identifiers

PMID: 18371340
DOI: 10.1016/j.stem.2007.03.002
PMCID: PMC2920603

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.PMID 18371340Read ↗

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