Article
In vivo cocaine experience generates silent synapses.
Neuron - 16 Jul 2009
Huang Yanhua H, Lin Ying, Mu Ping, Lee Brian R, Brown Travis E, Wayman Gary, Marie Helene, Liu Wenhua, Yan Zhen, Sorg Barbara A, Schlüter Oliver M, Zukin R Suzanne, Dong Yan
Abstract excerpt
Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little is known about whether silent synapses can be generated postdevelopmentally. Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (NAc) shell, a key brain region...
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