Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZO-1 determines adherens and gap junction localization at intercalated disks

4 Dec 2010

Abstract excerpt

The disruption of the spatial order of electromechanical junctions at myocyte-intercalated disks (ICDs) is a poorly understood characteristic of many cardiac disease states. Here, in vitro and in vivo evidence is provided that zonula occludens-1 (ZO-1) regulates the organization of gap junctions (GJs) and adherens junctions (AJs) at ICDs. We investigated the contribution of ZO-1 to cell-cell junction localization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Connexins and lens biology
Share to Ion channel regulation and function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21131473
DOI: 10.1152/ajpheart.00999.2010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

ZO-1 determines adherens and gap junction localization at intercalated disksPMID 21131473Read ↗

Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure.Semantic proximity Read ↗

Refining the molecular organization of the cardiac intercalated disc.Semantic proximity Read ↗

Dissociated Spatial Patterning of Gap Junctions and Cell Adhesion Junctions During Postnatal Differentiation of Ventricular MyocardiumSemantic proximity Read ↗

Assembly of the Cardiac Intercalated Disk during Pre- and Postnatal Development of the Human HeartSemantic proximity Read ↗

Myozap, a Novel Intercalated Disc Protein, Activates Serum Response Factor–Dependent Signaling and Is Required to Maintain Cardiac Function In VivoSemantic proximity Read ↗

N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility.Semantic proximity Read ↗

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.Semantic proximity Read ↗

ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton.Semantic proximity Read ↗

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.