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Defective Chromatin Structure in Somatic Cell Cloned Mouse Embryos

15 Jul 2009

Abstract excerpt

Epigenetic reprogramming plays a central role in the development of cloned embryos generated by somatic cell nuclear transfer, and it is believed that aberrant reprogramming leads to the abnormal development of most cloned embryos. Recent studies show that trimethylation of H3K27 (H3K27me3) contributes to the maintenance of embryonic stem cell pluripotency because the differentiation genes are always occupied by...

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PMID: 19602512
DOI: 10.1074/jbc.m109.011973

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