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Article

Gradual DNA demethylation of the <i>Oct4</i> promoter in cloned mouse embryos

24 Oct 2005

Abstract excerpt

During differentiation, somatic cell nuclei acquire unique patterns of epigenetic modifications, such as DNA methylation, which affect the transcriptional activity of specific genes. Upon transfer into oocytes, however, the somatic nucleus undergoes reprogramming of these epigenetic modifications to achieve pluripotency. Oct4 is one of the critical pluripotency regulators, and is expressed in the germ line,...

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PMID: 16245355
DOI: 10.1002/mrd.20411

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