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Article

Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro.

World journal of gastroenterology - 14 Jul 2009

Liu Li-Xin, Huang Shuai, Zhang Qian-Qian, Liu Yi, Zhang Dong-Mei, Guo Xiao-Hong, Han De-Wu

Abstract excerpt

AIM: To investigate the role of insulin-like growth factor binding protein-7 (IGFBP-7) in the activation and transdifferentiation of hepatic stellate cells (HSC) in vitro. METHODS: Rat HSC-T6 cells were cultured in separate dishes and treated with various concentration of transforming growth factor (TGF)-beta(1), IGFBP-7 or anti-IGFBP-7 antibody for 24 h. The supernatant or a cytoplasm suspension was obtained...

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Identifiers

PMID: 19598300
DOI: 10.3748/wjg.15.3246
PMCID: PMC2710780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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