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Article

Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation

1 Jan 2010

Abstract excerpt

AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT...

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PMID: 20976841
DOI: 10.3748/wjg.v16.i40.5047

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