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Article

Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats

25 Nov 2006

Abstract excerpt

BACKGROUND: Liver cirrhosis, which is caused by the accumulation of extracellular matrix materials, is a serious clinical problem that can progress to hepatic failure. Transforming growth factor-beta (TGFbeta) plays a pivotal role in extracellular matrix production, but bone morphogenetic protein (BMP)-7, a member of the TGFbeta superfamily, can antagonise the fibrogenic activity of TGFbeta. AIM: In this study,...

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PMID: 17127702
DOI: 10.1136/gut.2006.092460

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