Article
Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth.
Human genetics - 1 Nov 2009
Li Yufeng, Ni Rong, Song Wei, Shao Wenshuo, Shrestha Sadeep, Ahmad Sushma, Cunningham Coleen K, Flynn Patricia M, Kapogiannis Bill G, Wilson Craig M, Tang Jianming
Abstract excerpt
To confirm and refine associations of human leukocyte antigen (HLA) genotypes with variable antibody (Ab) responses to hepatitis B vaccination, we have analyzed 255 HIV-1 seropositive (HIV(+)) youth and 80 HIV-1 seronegatives (HIV(-)) enrolled into prospective studies. In univariate analyses that focused on HLA-DRB1, -DQA1, and -DQB1 alleles and haplotypes, the DRB1*03 allele group and DRB1*0701 were negatively...
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