Article
HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination.
Hepatology (Baltimore, Md.) - 1 Apr 2004
Wang Chengbin, Tang Jianming, Song Wei, Lobashevsky Elena, Wilson Craig M, Kaslow Richard A
Abstract excerpt
Variable immune responses to hepatitis B virus (HBV) infection and recombinant HBV vaccines have been associated with polymorphisms in several genes within the human leukocyte antigen (HLA) complex. Analyses of polymerase chain reaction (PCR)-based genotyping data from 164 North American adolescents vaccinated with recombinant HBV products confirmed that HLA-DRB1*07 (relative odds [RO] = 5.18, P <.0001) and human...
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