A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.

doi:10.1093/hmg/ddr302

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Article

A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.

Human molecular genetics - 1 Oct 2011

Png Eileen, Thalamuthu Anbupalam, Ong Rick T H, Snippe Harm, Boland Greet J, Seielstad Mark

Abstract excerpt

We performed a two-stage genome-wide association study (GWAS) of antibody titer in 3614 hepatitis B vaccine recipients from Indonesia's Riau Archipelago, leading to the identification of at least three independent signals within the human leukocyte antigen (HLA) complex. These appear to implicate HLA-DR [rs3135363; P= 6.53 × 10(-22); odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.35-1.74]; HLA-DP,...

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PMID: 21764829
DOI: 10.1093/hmg/ddr302

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