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Article

Response to hepatitis B vaccine: multiple HLA genes are involved.

Tissue antigens - 1 Jun 1998

Desombere I, Willems A, Leroux-Roels G

Abstract excerpt

The mechanism underlying the impaired immune response to hepatitis B vaccines in up to 10% of healthy subjects is not known. An increased incidence of poor responsiveness in subjects with HLA-DR3+ or -DR7+ haplotypes has been documented, suggesting that HLA-DR-linked genes may regulate the human...

Topics

Adult
HLA-DP Antigens
HLA-DP beta-Chains
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains
Hepatitis B Vaccines
Histocompatibility Testing
Humans
Phenotype

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Source

Identifiers

PMID: 9694351
DOI: 10.1111/j.1399-0039.1998.tb03001.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9694351-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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