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Article

Response to hepatitis B vaccine: multiple HLA genes are involved.

Tissue antigens - 1 Jun 1998

Desombere I, Willems A, Leroux-Roels G

Abstract excerpt

The mechanism underlying the impaired immune response to hepatitis B vaccines in up to 10% of healthy subjects is not known. An increased incidence of poor responsiveness in subjects with HLA-DR3+ or -DR7+ haplotypes has been documented, suggesting that HLA-DR-linked genes may regulate the human response to hepatitis B surface antigen. However, not all HLA-DR3+ and/or -DR7+ individuals are poor responders, and...

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Source

Identifiers

PMID: 9694351
DOI: 10.1111/j.1399-0039.1998.tb03001.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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