Article
Distinct HLA class II alleles determine antibody response to vaccination with hepatitis B surface antigen.
Kidney international - 1 Jun 1998
Caillat-Zucman S, Gimenez J J, Wambergue F, Albouze G, Lebkiri B, Naret C, Moynot A, Jungers P, Bach J F
Abstract excerpt
Major histocompatibility complex (MHC) determinants control antibody production in response to protein antigens. Vaccination with hepatitis B surface antigen (HBsAg) frequently fails in hemodialyzed patients, but the genetic factors that modulate humoral responsiveness are poorly characterized. W...
Topics
- Alleles
- Antibody Formation
- Female
- Gene Frequency
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Hepatitis B
- Hepatitis B Antibodies
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Histocompatibility Antigens Class II
- Humans
- Male
- Middle Aged
- Phenotype
- Vaccination